ePoster listing and sessions

Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London

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5-year real life evaluation of orbital biopsies: Accuracy between clinical and radiological diagnoses compared to surgical orbital biopsies

Author: Audrey Tang
ePoster Number: 232


Surgical orbital biopsy is essential in diagnosing orbital lesions of unknown aetiology. There has been limited research comparing the consistency between diagnoses from clinical examination, imaging reports and histological results. Concordance between the three diagnoses is evaluated in this study.


A retrospective case note review analysed all patients within a single hospital trust who had undergone surgical orbital biopsies between 1st January 2015 to 31st December 2019. Accuracy of and concordance between the clinical, radiological and histological diagnoses are reported as percentage sensitivity and positive predictive value (PPV).


132 procedures involving 115 patients were identified. Three histological samples from biopsies were inconclusive; no clinical diagnoses were offered in 15 cases. Radiological imaging was done in 111 cases, but no diagnoses were offered in 14 cases. Sensitivities of 46.2% and 37.8% were found in clinical and radiological diagnoses respectively when compared with histological diagnoses. Inflammatory conditions showed the lowest sensitivity in both clinical (30.3%) and radiological (18.2%) diagnoses. The PPV were 47.6% and 30.0% for clinical and radiological diagnoses of inflammatory lesions respectively. Vascular lesions, which are believed to have characteristic features both clinically and radiologically, had the highest sensitivity (71.4% and 57.1% respectively). There was no operative mortality, and no post-operative complications were recorded.


Accurate diagnoses are difficult to reach by relying on clinical examination and imaging alone. Surgical orbital biopsy should remain the gold-standard tool in identifying aetiology of orbital lesions with unknown origins.

Additional Authors

First nameLast nameBase Hospital / Institution
HelenNgUniversity of Leeds
TarasGoutSt. James’ University Hospital Leeds
BernardChangSt. James’ University Hospital Leeds
GeorgeKalantzisSt. James’ University Hospital Leeds

Abstract ID: 21-123