ePoster listing and sessions

Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London

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Fibrotic changes in tear ducts after exposure to radioactive iodine and in primary obstruction

Author: Vasily Yartsev
ePoster Number: 239


Purpose

Systemic exposure to radioiodine leads to the development of nasolacrimal duct obstruction. Clinical experience has shown that in such cases obstruction is primarily formed in the distal parts of the tear ducts.The aim is a morphological assessment of fibrosis of the tear ducts in their primary and secondary acquired obstruction at various anatomical levels.


Methods

After radioiodine therapy in patients (n=5) with primary obstruction of the tear duct (PANDO) and patients (n=5) with secondary obstruction (SALDO) fragments of the nasolacrimal duct opening and lacrimal sac were obtained. They were studied by the method of light microscopy histologically (hematoxylin and eosin staining) and histochemically (Masson staining). Using the ImageJ 1.51 software (NIH, USA) a quantitative characterization of the fibrous component was given. In each case, three microscope slides were studied to determine the average value of the number of collagen and elastic fibers as well as their ratio. The Mann-Whitney test was used. Differences were considered significant at p<0.05.


Results

A significant difference (p=0.029) was obtained when comparing the distribution of collagen fibers in the lacrimal sac and nasolacrimal duct in patients with SALDO. No differences were found in PANDO patients. When comparing the distribution of elastic fibers, no differences were found.


Conclusion

Lacrimal ducts fibrosis depends on their anatomical level in patients with SALDO and it is the same in patients with PANDO regardless of the anatomical level. It confirms the hypothesis that radiation injury develops at the opening of the nasolacrimal duct, while damage in the proximal regions is secondary.


Additional Authors

First nameLast nameBase Hospital / Institution
EugeniaAtkovaScientific Research Institute of Eye Diseases
GrigoriyDemyashkinI.M. Sechenov First Moscow State Medical University (Sechenov University)
VladimirShchekinI.M. Sechenov First Moscow State Medical University (Sechenov University)
MaximEkaterinchevScientific Research Institute of Eye Diseases

Abstract ID: 21-134