ePoster listing and sessions

Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London

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A novel description of a CD34-positive fibroblastic tumor of the orbit.

Author: Celia García-López
ePoster Number: 118


To describe a unique case of a CD34-positive fibroblastic tumor of the orbit and review the medical literature regarding this unusual topic.


Case report and literature review.


A 57-year-old male presented with 6-months symptoms of painless right proptosis and diplopia. He had a complex medical history including left renal, and bladder malignancies treated 5 years before. Examination revealed a right proptosis and ocular motility restriction in up gaze. A firm mass was noticed in the upper lid. The mass was visible on the upper conjunctival fornix with a smooth surface and salmon-colored aspect.
CT scan revealed a homogeneous intraconal mass in contact with the eyeball, medial rectus muscle, and the optic nerve, and extending to the upper orbit. The MRI study showed an irregular-shaped tumor, hypointense on T1, and hyperintense on T2. PET-TC showed no other suspicious images.
An incisional biopsy was performed. Surprisingly, H&E staining revealed a mesenchymal aspect and myxoid growth pattern. Cells had prevailing spindle‑to‑oval‑shaped cells with abundant euchromatin‑prominent nucleoli and intranuclear pseudo inclusions. Ki67 index was 15-20%. Immunohistochemistry showed an intense positivity for CD34, focal positivity for CD56. Other markers were negative.


The CD34 positive mesenchymal tumors are very rare. CD34-positive fibroblastic tumor (SCPFT) is an uncommon and recently described neoplasm of borderline malignancy which is typified for marked cellular pleomorphism, low mitotic figures, and strong CD34 immunohistochemical positivity. Although the features of the tumor matched with the case, SCPFT had never been described before in orbital location in the literature. 
Due to rapid growth after 2 months and the infiltrative nature of the tumor, an orbital exenteration and reconstruction with temporal muscle flap were performed.
After 14 months of follow-up, no complications or recurrence of the tumor have been reported.

Additional Authors

First nameLast nameBase Hospital / Institution
CarlosGálvez Prieto-MorenoUniversitary Hospital Virgen de las Nieves, Granada, Spain
CarlosMilla-PeñalverUniversitary Hospital Virgen de las Nieves, Granada, Spain
AurelioMartín-CastroUniversitary Hospital Virgen de las Nieves, Granada, Spain
Ana BelénMarín-FernándezUniversitary Hospital Virgen de las Nieves, Granada, Spain
SantiagoOrtiz-PerezUniversitary Hospital Virgen de las Nieves, Granada, Spain

Abstract ID: 21-180