Clinicopathological Correlation and Analysis of Lacrimal System Lesions
Author: Merve Kulbay
Base Hospital / Institution: McGill University Health Centre
ePoster presentation
Abstract ID: 25-592
Purpose
Lacrimal system diseases encompass a wide range of diagnoses, from benign to malignant lesions, and are typically categorized as either inflammatory, lymphoproliferative or of other neoplastic nature. Clinically, these lesions are difficult to differentiate based solely on symptomatology and clinical examination, making tissue biopsies the gold standard for definitive histopathological diagnosis. The aim of this study was to analyze the characteristics of clinical diagnosis and histopathological features of lacrimal system lesions to clarify the epidemiological distribution of lesions while improving diagnostic precision and patient prognosis.
Methods
A total of 115 biopsies from the MUHC – McGill University Ocular Pathology & Translational Research Laboratory were studied to determine the clinicopathological characteristics of various lacrimal system lesions. Data on age, sex, location, clinical diagnosis, and histopathological features were collected and analyzed.
Results
In the 115 lacrimal system biopsies, the average age was 60.23 ± 19.21 years. Biopsy sites were relatively evenly distributed among the right eye (51%) and the left eye (46%), with 3% of locations unspecified. Overall, 24 different diagnoses were identified among the patients. The most common clinical indications for biopsy were dacryocystitis (47/115), followed by dacryostenosis (12/115), and potential malignancies (12/115). Accurate clinicopathological correlation was detected in 81% of cases. Dacryocystitis showed the greatest concordance rate (93%), whereas discrepancies were noted in clinical situations suspecting neoplastic etiology (82%).
Conclusion
To the best of our knowledge, this study represents the largest cohort of biopsied lacrimal system lesions to date. Our findings highlight the difficulty in diagnosing benign and malignant lesions solely based on clinical assessment. Clinicopathological correlation with histopathological interpretation is essential for the final correct diagnosis.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Roxana | Barin | |
| William | Sebag | |
| Emily | Marcotte | |
| Coralie | Lefebvre | |
| Mohamed | Abdouh | |
| Bryan | Arthurs | McGill University Health Centre |
| Christian | El-Hadad | McGill University Health Centre |
| Miguel N. | Burnier | McGill University Health Centre |
