Exploring Obstetric Risk Factors and Pathophysiological Mechanisms in Simple Congenital Ptosis
Author: Konstantin Gushansky
Base Hospital / Institution: Shaare Zedek Medical Center
ePoster presentation
Abstract ID: 24-102
Purpose
This pilot study aims to explore additional obstetric risk factors associated with Simple Congenital Ptosis (SCP) and elucidate potential underlying pathophysiological mechanisms.
Methods
A retrospective cohort study was conducted by analyzing electronic medical records of mothers and newborns diagnosed with SCP between 2002 and 2022. Inclusion criteria encompassed SCP diagnosed before 3 months of age. Cases linked to specific origins (e.g., traumatic), syndromes (e.g., Duane), or established risk factors (vacuum, forceps, dystocia) were excluded.
Results
Our cohort of 51 SCP cases had significantly lower gestational age (38.5 vs. 39.1 weeks, p=0.012) and lower birth weight (2998 vs. 3255 grams, p<0.001) compared to the general population. SCP cases also exhibited a higher incidence of gestational diabetes mellitus (11.8% vs. 5%, p=0.026) and preterm deliveries (15.7% vs. 0.05%, p<0.001), and a lower incidence of large-for-gestational-age newborns (0% vs. 9.6%, p=0.026).
Conclusion
This study identifies novel associations between SCP and obstetric factors such as gestational diabetes mellitus and preterm labor, suggesting a potential link to lower Insulin-like Growth Factor 1 levels. Early ophthalmology checkups for low birth weight infants born to diabetic mothers could mitigate SCP-related risks. These findings enhance the current understanding of congenital ptosis, potentially facilitating early diagnosis and treatment of this vision-threatening condition.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Achia | Nemet | Shaare Zedek Medical Center |
| Raimo | Tuuminen | Shaare Zedek Medical Center |
