Magnetic Resonance Diffusion-Weighted Imaging in Lacrimal Gland Lymphoma vs. Inflammation: A Comparative Study
Author: Daphna Landau
Base Hospital / Institution: Sheba Medical Center
ePoster presentation
Abstract ID: 24-148
Purpose
To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) in differentiating inflammatory process and malignant lymphoma of the lacrimal gland.
Methods
A retrospective analysis of all subjects who underwent lacrimal gland biopsy and MR imaging with DWI sequences during a 10-year period at the Sheba Medical Center, Israel. The lacrimal glands’ ADC values were documented bilaterally by blinded observers and correlated with the final histology verified diagnoses.
Results
Twenty-eight patients were included, 19 females (68%) with mean±SD age of 48.1±25.7 years. The right orbit was involved in 14 cases (50%), left in 13 (46%); one patient (4%) had bilateral involvement. Seventeen cases (61%) had a final diagnosis of idiopathic inflammation or dacryoadenitis, and six cases (21%) were diagnosed with lymphoma. Additional diagnoses included pleomorphic adenoma in 3 (11%), adenoid cystic carcinoma, and solitary fibrous tumor. Lower mean ADC values were observed in the lymphoma vs. inflammatory group (1.03X10-3 Vs. 1.45X10-3, P=0.02).
Conclusion
Restricted diffusion on MR imaging can serve as a diagnostic tool in the differentiation between inflammatory processes of the lacrimal gland and lymphoma.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Rachel | Shemesh | Sheba Medical Center |
| Dafna | Shalev | Sheba Medical Center |
| Malachy | Nemet | Sheba Medical Center |
| Guy J. | Ben-Simon | Sheba Medical Center |
| Gahl | Greenberg | Sheba Medical Center |
