Abstract Listings 2024

Purpose

Xanthelasma Palpebrarum (XP) is a benign condition involving yellowish cutaneous lesions in the periocular region. Various studies have suggested associations between XP and systemic disorders, mainly dyslipidemia and cardiovascular disease (CVD). It is believed that associated lipid disorders appear in nearly half of the patients, and XP patients are commonly referred for further evaluation. Our aim was to inspect whether XP is associated with dyslipidemia or CVD in a large cohort.

Methods

Medical records of all patients who were examined in a single medical screening institute between 2001-2020 were retrospectively analyzed. Patients with XP in at least one eye were identified. Controls were matched on a 1:10 ratio for robust statistical comparisons. Data regarding ophthalmic evaluations, blood tests, and systemic diagnoses was collected and analyzed. Main outcome measure included the associations of XP with dyslipidemia and CVD.

Results

35,678 patients were included, 203 patients (0.6%) had XP and were matched with 2030 control cases. The prevalence of dyslipidemia diagnosis and the usage rates of statins, fibrates, or other cholesterol-lowering medications was similar between the two groups. Lipid profiles were similar between the groups, including median total cholesterol levels, HDL, LDL, and triglyceride (P>0.05 for all). The rate of CVD was similar as well. The prevalences of related conditions including HTN, DM, and history of CVA were similar between groups.

Conclusion

XP was not associated with dyslipidemia or CVD. This questions current clinical management concepts regarding the need to send all XP patients for blood tests and cardiovascular workups.

Additional Authors

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