Efficacy and safety of Lipiflow® in the treatment of dry eye disease due to Meibomian gland dysfunction: an updated meta-analysis of randomized controlled trials
Author: Saleha Azeem
Base Hospital / Institution: King Edward Medical University
ePoster presentation
Abstract ID: 24-173
Purpose
This study aims to assess the efficacy and safety of Lipiflow® as compared to warm compress and other thermal pulsatile systems (TPSs) in the treatment of dry eye disease (DED) resulting from Meibomian gland dysfunction (MGD).
Methods
Randomized clinical trials (RCTs) were searched in MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Web of Science and Google Scholar from inception up to January 2024. The primary outcomes were Meibomian gland function, subjective symptoms as measured by the Standard Patient Evaluation of Eye Dryness (SPEED), and subjective symptoms as measured by the Ocular Surface Disease Index (OSDI). The secondary outcomes were Meibomian glands yielding liquid secretion (MGYLS), Meibomian glands yielding secretion score (MGYSS), corneal fluorescein staining (CFS), tear breakup time (TBUT), and adverse events.
Results
A meta-analysis was performed on 1688 patients from 17 RCTs. Between the Lipiflow® group and a warm compress control group, a significant increase was observed in Meibomian Gland Function, MGYLS score, and MGYLSS and a significant decrease in SPEED score, OSDI score, and CFS, with no difference in TBUT and adverse events. Between the Lipiflow® group and another TPS control group, none of the outcomes were statistically significant including Meibomian gland function, OSDI score, MGYLS score, MGYSS score, CFS, TBUT, and adverse events.
Conclusion
Lipiflow® treatment, in comparison with warm compress, is more effective in improving the subjective and objective outcomes of MGD, with no rise in adverse events. There is no statistically significant difference in outcomes between Lipiflow® and other thermal pulsatile systems.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Luqman | Munir | King Edward Medical University |
| Mohammad | Ammar ur Rahman | King Edward Medical University |
| Zainab | Jamil | King Edward Medical University |
| Mohsin | Rashid | King Edward Medical University |
| Sarah | Aman | Wilmer Eye Institute |
| King Edward Medical University |
