Complications after radiation therapy in patients with thyroid-associated orbitopathy: A nationwide cohort study
Author: Jeong Kyu Lee
Base Hospital / Institution: Chung-Ang University Hospital
ePoster presentation
Abstract ID: 24-207
Purpose
The aim of this research was to evaluate the complications following radiation therapy in individuals with thyroid-associated orbitopathy (TAO) and to identify the risk factors associated with the development of radiation retinopathy.
Methods
A retrospective cohort study was conducted using a specialized database obtained from the National Health Insurance Service, which included 44,833 subjects diagnosed with TAO between 2008 and 2018. The analysis utilized the Korean Classification of Diseases to assess the incidence of cataracts, ocular surface diseases, dry eye, eyelid inflammation, radiation retinopathy, head and neck cancer, as well as leukemia and lymphoma following radiation therapy in TAO patients. A logistic regression model was used to examine the risk factors associated with the development of radiation retinopathy.
Results
Between 2008 and 2018, 1,101 patients underwent radiation therapy for TAO. Among them, 67 patients (6.1%) were newly diagnosed with cataracts after radiation therapy, and 42 patients (3.8%) required cataract surgery. Ocular surface disease affected 14 patients (1.3%); dry eye impacted 36 individuals (3.3%); eyelid inflammation was observed in 8 patients (0.7%); head and neck cancer affected 2 individuals (0.2%); and no cases of leukemia or lymphoma were reported. Radiation retinopathy was detected in 64 patients (5.8%). Logistic regression analysis identified a short period between TAO diagnosis and radiation treatment, elevated fasting blood sugar levels, and a history of cardiovascular disease as significant risk factors for radiation retinopathy.
Conclusion
Complications following radiation therapy for TAO were relatively infrequent. It is imperative to closely monitor the development of radiation retinopathy in patients undergoing radiation therapy for TAO, especially those with a short disease duration, elevated fasting blood glucose levels, and a history of cerebrovascular disease.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Jung Sun | Heo | Chung-Ang University Hospital |
