Abstract Listings 2024

Purpose

This study aims to elucidate the demographic profile and treatment outcomes of diverse histopathological subtypes of non-BCC eyelid malignancies.

Methods

We conducted a retrospective analysis of 82 cases of non-BCC eyelid malignancies treated at Leicester Royal Infirmary over a 14-year period. Excel and JASP statistical software were utilised for the data analysis.

Results

The study included 82 patients, with an average age of 74 years. Fifteen histological subtypes were observed, with squamous cell carcinoma and sebaceous cell carcinoma being the two most common. Patients were, on average, monitored for a duration of 46.2 months, with a follow up period ranging from 1 to 228 months. Further excision was necessary in 54% of cases, with a notably high rate observed in lentigo maligna (76%, p 0.201). Local recurrence occurred in 14% of cases, with elevated rates noted in lentigo maligna (25%) and merkel cell carcinoma (100%). Distant metastasis was detected in 4% of cases, all of which were squamous cell carcinoma (12%). Surgical excision was the primary treatment modality for most cases (86%). Radiotherapy was required in 9% of cases, while chemotherapy was necessary in 9% of cases. Exenteration was deemed necessary in 5% of cases.

Conclusion

The study encompassed a diverse range of histopathological subtypes. The findings underscore the importance of vigilant monitoring, as evidenced by the varied rates of local recurrence and distant metastasis among different subtypes. Surgical excision remains the cornerstone of treatment, with staged excision followed by reconstruction yielding favourable outcomes in the majority of cases. However, the occasional necessity for adjuvant therapies such as radiotherapy, chemotherapy, as well as more aggressive interventions like exenteration in select cases. Moving forward, continued research and multidisciplinary approaches will be crucial in refining treatment strategies and improving long-term outcomes for patients with non-BCC eyelid malignancies.

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