OPTIMIZATION OF THE USE OF CO2 FRACTIONAL ABLATIVE LASER WITH EXOSOMES, ADSC, PRP AND RESVERATROL: A SYSTEMATIC REVIEW
Author: Malú Inês Perez Moura
Base Hospital / Institution: UNIOFTAL- Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil.
ePoster presentation
Abstract ID: 24-306
Purpose
It was to carry out a systematic review to list the main clinical outcomes of using fractional ablative CO2 laser with exosomes, adipose-derived stem cell (ADSC), platelet-rich plasma (PRP), and resveratrol for facial aesthetic treatment.
Methods
The systematic review rules of the PRISMA Platform were followed. The research was carried out from January to March 2024 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE and AMSTAR-2 instruments and the risk of bias was analyzed according to the Cochrane instrument and Funnel Plot (Cohen Test).
Results
A total of 86 articles were found. 32 articles were fully evaluated and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies at high risk of bias and 37 that did not meet the GRADE and AMSTAR-2. The results demonstrate that the low-fluence, low-density fractional CO2 ablative laser is a safe and efficient option for facial photorejuvenation. Repeated application of ablative fractional CO2 laser to melasma skin can result in lasting improvement due to its destructive effect on melanocytes. Furthermore, the combined use of exosome gel with CO2 laser resurfacing would provide synergistic effects on both the efficacy and safety of treatments for atrophic acne scars. Furthermore, adipose-derived stem cells (ADSC) and platelet-rich plasma (PRP) with CO2 resurfacing are good combination therapy for the treatment of atrophic acne scars and skin rejuvenation.
Conclusion
With the combined use of ablative fractional CO2 laser, adipose-derived stem cells, and platelet-rich plasma obtained better results. Resveratrol can improve photoaging alone add efficacy to fractional ablative laser treatment and decrease the adverse effects induced by fractional ablative laser.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Fernanda | Soubhia Liedtke | UNIOFTAL- Ophthalmology And Eye Plastic, São José do Rio Preto, São Paulo, Brazil. |
| Idiberto Jose | Zotarelli-Filho | UNESP – São Paulo State University. Institute of Biosciences, Humanities and Exact Sciences (Ibilce), Postgraduate Program in Food, Nutrition and Food Engineering, Campus São José do Rio Preto, SP, Brazil; and, ABRAN – Associação Brasileira de Nutrologia/Brazilian Association of Nutrology, Catanduva, Sao Paulo, Brazil. |
