Impact of Histopathological Features of Levator Aponeurosis/Levator Palpebrae Superioris Muscle on Levator Function in Blepharoptosis Surgery
Author: Bilge Tarim
Base Hospital / Institution: Department of Ophthalmology, Beypazari State Hospital, Ankara, Turkey
ePoster presentation
Abstract ID: 24-401
Purpose
This study aims to investigate the histopathological features of the levator aponeurosis (LA)/levator palpebrae superioris (LPS) muscle in patients undergoing blepharoptosis surgery.
Methods
Files of patients who presented with blepharoptosis and underwent LA/LPS muscle surgery were reviewed. The age, gender, and preoperative levator functions (LF) of the included patients were noted. The presence of fat tissue, fibrous tissue, inflammation, edema, and fat/muscle ratio were examined in the LA/LPS muscle samples. Patients with LF over 14 mm were classified as Group 1, and those with 14 mm and below were classified as Group 2.
Results
Group 1 consisted of 20 patients, Group 2 consisted of 18 patients, and the groups were statistically similar in terms of gender and age (p = 0.095; p = 0.661). The average LF was 16.50 ± 2.14 mm in Group 1 and 10.00 ± 2.61 mm in Group 2 (p < 0.001). Although not statistically significant, more cases of fat tissue in the LA/LPS muscle were found in Group 2 (p = 0.093). The fibrous tissue components were similar in both groups (p = 0.994). No inflammation was detected in 90% of Group 1 and 94.4% of Group 2 (p = 1.00). Mild to moderate edema was detected in 95% of Group 1 and 89% of Group 2 (p = 0.382). The mean rank of fat/muscle ratio was 16.98 in Group 1 and 22.31 in Group 2. Although not statistically significant, the fat/muscle ratio was higher in Group 2, indicating more fatty degeneration (p: 0.136). The correlation analyses revealed that, although not statistically significant, a higher fat/muscle ratio and the presence of fat tissue negatively affected LF (r = -0.162, p = 0.331; r = -0.226, p = 0.172). No statistically significant relationship was found between the presence of fibrous tissue, inflammation, and edema at the histopathological level and LF.
Conclusion
The presence of fat tissue in the LA/LPS muscle seems to negatively affect LF. It is likely that LPS function is determined by innervational features as much as changes in muscle tissue. More comprehensive results can be obtained by increasing the number of patients in the study and examining more specific histological markers.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Huban Sibel | Orhun | Ankara Bilkent City Hospital Medical Pathology Department, Ankara, Turkey |
| Nilay | Yuksel | University of Health Sciences Ankara Bilkent City Hospital Ophthalmology Department, Ankara, Turkey |
