Orbital Solitary Fibrous Tumour: Longterm Outcome Following Treatment with Orbital Radiotherapy
Author: Gabriella Guevara
Base Hospital / Institution: Moorfields Eye Hospital
ePoster presentation
Abstract ID: 24-500
Purpose
To describe the long-term clinical outcome and radiological evaluation following treatment with orbital radiotherapy for a large WHO high grade orbital solitary fibrous tumour (SFT).
Methods
Our female patient was first referred to our institution in 2016 aged 55 with an incidental lesion in her right superior orbit and a previous history of Graves’ disease and congential dischromatopsia. The lesion remained stable until 2020 when she developed unilateral right proptosis and chemosis. Incisional biopsy was performed and confirmed a histopathological diagnosis of a WHO high grade solitary fibrous tumour with a high mitotic rate. Due to the large size and position of the lesion complete surgical excision was not possible and the patient declined exenteration but elected to proceed with orbital radiotherapy. The patient received 44Gy/22 Fractions in 2021 and has had serial clinical and radiological evaluation since.
Results
At 3 year follow up the patient retains 6/5 visual acuity unaided with normal ocular motility and no RAPD. Sequential orbital imaging has demonstrated involution and regression of her tumour which has continues to reduce in size.
Conclusion
Orbital SFTs are rare spindle cell tumours of mesenchymal origin. Complete surgical excision is the current standard of treatment to prevent recurrence. There are no current published studies on the evaluation of radiation. Our case suggests that radiotherapy may reduce the size of SFT with persistent disease control without compromising visual function. The significant reduction in tumour size seen also suggests that radiotherapy could be considered as an adjunct to surgery.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Katherine | Miszkiel | Moorfields Eye Hospital |
| Geoff | Rose | Moorfields Eye Hospital |
| David | Verity | Moorfields Eye Hospital |
