Non-specific orbital inflammation : Clinical features and outcomes
Author: Rahma Bel Hadj Letaief
Base Hospital / Institution: Fattouma Bourguiba University Hospital
ePoster presentation
Abstract ID: 24-505
Purpose
To describe clinical features and outcomes of non-specific orbital inflammation.
Methods
This is a retrospective review of the charts of 40 patients (40 eyes) diagnosed with non-specific orbital inflammation at Fattouma Bourguiba hospital, Monastir, Tunisia, from January 2007 to December 2023. All patients underwent a complete ophthalmological examination and orbital and head CT scan and/or MRI.
Results
The mean age of patients was 42.2 years (range, 16-75). The sex ratio (H/F) was 0.6. Involvement was unilateral in all cases. Orbital pain was the most common presenting symptom (22 patients, 55%), followed by proptosis (18 patients, 45%), and decreased vision (11 patients, 27.5%). Mean best-corrected visual acuity at presentation was 20/40 (range :20/4000 and 20/20). Ophtalmological examination showed conjunctival hyperemia and/or chemosis in 31 patients (77%), oculomotor disorders in 21 patients (52%), lacrimal gland enlargement in 3 patients (7.5%), and elevated intraocular pressure in 3 patients (7.5%). Fundus examination showed optic disc edema in 6 eyes (15%), retinal folds in 5 eyes (12.5%), signs of central retinal arterial occlusion in 2 eyes (5%), and optic disc atrophy in one eye (2,5%). Orbital imaging showed oculomotor muscle inflammation in 25 eyes (62.5%) and inflammation of orbital fat in 19 eyes (47.5%). A work-up was performed in all cases to rule out local causes and systemic disease. Biopsy was performed in 11 patients (27.5%), showing non-specific inflammation (10 patients, 91%) and the sclerosing form (one patient, 9%). Twenty five (62,5%) patients received oral corticosteroids. Immunosupressive therapy was indicated in 3 patients (7.5%). Mean follow up was 9 months (range, 6 and 30). Nine patients (22.5%) suffered relapses within the follow‐up period.
Conclusion
Non-specific orbital infammation is a diagnosis of exclusion, based on history, clinical course, response to steroid therapy, laboratory tests, or even biopsy in selected cases. Orbital imaging provides valuable clues for diagnosis and for identification of the affected structures. Despite treatment relapses often occur.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Wijden | Nabi | Fattouma Bourguiba University Hospital |
| Chaima | Hamdi | Fattouma Bourguiba University Hospital |
| Touka | Ben Mabrouk | Fattouma Bourguiba University Hospital |
| Sana | Khochtali | Fattouma Bourguiba University Hospital |
| Moncef | Khairallah | Fattouma Bourguiba University Hospital |
