Disseminated Molluscum Contagiosum in Autosomal Recessive Hyperimmunoglobulin E Syndrome
Author: Asma Alhazmi
Base Hospital / Institution: King Fahd Hospital of the University
ePoster presentation
Abstract ID: 25-478
Purpose
We report a case of a 5-year-old girl who presented to our clinic with widely disseminated molluscum contagiosum (MC) lesions and a history of atopic eczema.
Methods
Cutaneous examination revealed multiple, scattered, flesh-colored, umbilicated, firm, papules and nodules involving the mainly the periorbital region, as well as the post-auricular region, trunk, the upper and lower limbs.
Results
Previously administered treatments resulted in unsuccessful resolution of these skin lesions. Hyperimmunoglobulin E syndrome (HIES) was suspected and serum IgE levels were found to be markedly elevated.
Conclusion
HIES is a severe primary immunodeficiency, that presents with a clinical triad of severe dermatitis, recurrent infections, and a severely raised level of serum IgE. This rare multisystem disease involves the immune system, soft connective tissues, skeletal and dental abnormalities. It often presents sporadically, but autosomal dominant and autosomal recessive have been described. The autosomal recessive form is characterized by recurrent bacterial and viral infections, atopic eczema and high serum IgE. About 200 or more HIES cases have been documented in literature, HIES with severe MC is even less common with the first case reported around 2001. This paper aims to share the clinical course of such a rare disease.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Aysha | AlOqab | Bahrain Defence Force Hospital |
| Hala | Nassim | King Fahd Hospital of the University |
