Evaluating Tranexamic Acid’s Role in Blepharoplasty: A Systematic Review and Meta-Analysis
Author: Hashem Abu Serhan
Base Hospital / Institution: Hamad Medical Corporation
ePoster presentation
Abstract ID: 25-218
Purpose
To evaluate the efficacy of tranexamic acid (TXA) in blepharoplasty surgery.
Methods
A meta-analysis was conducted following PRISMA guidelines. PubMed, Web of Science, Cochrane Library, and Scopus databases were searched for randomized controlled trials (RCTs). Data extraction focused on outcomes such as ecchymosis scores, time to recovery, intraoperative pain, operative time, and hemostasis quality. The risk of bias was assessed using the ROB 2 tool. RevMan 5.4 software was used for meta-analysis with mean differences (MD) and standardized MD (SMD) calculated for various outcomes.
Results
Five RCTs comprising 594 participants (1154 eyes) met the inclusion criteria. Overall, TXA significantly reduced postoperative ecchymosis on postoperative days (POD) 1 and 7 (SMD = -0.54, 95% CI: [-0.71 to -0.38], p < 0.00001) with moderate heterogeneity (I² = 50%). TXA significantly shortened patient-reported recovery time (MD = -0.72 days, 95% CI: [-1.02 to -0.42], p < 0.00001) with homogeneity (I² = 0%). Although TXA reduced operative time, this was significant only for the intravenous route (MD = -2.10 minutes, 95% CI: [-3.71 to -0.49], p < 0.01). There was no significant difference in intraoperative pain scores or surgeon-assessed hemostasis quality for subcutaneous TXA; however, intravenous TXA improved hemostasis assessment (MD = -0.70, 95% CI: [-1.02 to -0.38], p < 0.0001).
Conclusion
TXA significantly reduces ecchymosis, expedites recovery, and enhances operative time and hemostasis in blepharoplasty. These findings support TXA’s use as an effective adjunct to improve blepharoplasty recovery, although further studies are warranted to optimize dosing and minimize thromboembolic risks.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Mohamed | Abo Zeid | Tanta University |
| Kareem | Khalefa | Tanta University |
| Mohamed Al Diab | Al Azzawi | National Ribat University |
| Amr | Elrosasy | Cairo University |
| Amr M. | Abou Elezz | Tanta University |
| Mohamed S. I. | Mohamed | Qatar University |
| Richard C. | Allen | University of Texas |
