From Scalpel to Syringe: Intralesional IL2-based therapy is effective for locally advanced periocular cutaneous squamous cell carcinoma
Author: Ahsen Hussain
Base Hospital / Institution: Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada
ePoster presentation
Abstract ID: 25-243
Purpose
Cutaneous squamous cell carcinoma (cSCC) is a common eyelid malignancy that is typically treated by surgical excision. Locally invasive periocular cSCC may not be amenable to surgery in cases where extensive resection would result in structural or functional compromise.
Methods
We report the first series of biopsy-confirmed periocular cutaneous squamous cell carcinoma (cSCC) cases treated with intralesional interleukin-2 (IL-2).
Results
Treatment courses for six patients are summarized, with one representative case detailed here. A 75-year-old male presented with a large, painful, centrally pedunculated mass on the left upper eyelid, measuring 5.5cm by 2.5cm. Mass excisional biopsy and reconstruction revealed moderately differentiated invasive SCC involving deep and peripheral margins. Given the risks associated with further resection, the patient opted to pursue local immunotherapy. He received five doses of intralesional IL2 every two weeks. The lesion was completely clinically cleared at six weeks, and there was no recurrence noted at 15-month follow-up.
Conclusion
Local intralesional IL2 therapy can be an effective treatment option for locally invasive periocular cSCC in cases that may result in significant functional or aesthetic compromise.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Sorayya | Seddigh | Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada |
| Freddy | Lee | Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada |
| Dejan | Vidovic | Division of General Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada |
| Jennette | Gruchy | Department of Pathology and Laboratory Medicine, Dalhousie University, Halifax, Nova Scotia, Canada |
| Carman | Giacomantonio | Division of General Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada |
