Abstract Listings 2025

Purpose

To analyze the clinical features, management, and survival outcomes of patients in whom orbital metastasis was the first sign of undiagnosed malignancy.

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Methods

This retrospective case series (2014–2022) included 10 patients (33.3% of 30 orbital metastasis cases) without prior cancer diagnosis. Data on demographics, clinical presentation, imaging (PET/CT), histopathology, treatment, and survival were analyzed. Ethical approval was obtained, adhering to the Declaration of Helsinki.

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Results

The cohort had a mean age of 68 years (range: 52–77), with female predominance (60%). Lung (40%) and breast (30%) were the most frequent primaries. Proptosis (90%), diplopia (60%), and ocular pain (50%) were common presenting symptoms. Systemic evaluation revealed disseminated disease (mean metastatic sites: 3.3). All patients received chemotherapy; 40% underwent radiotherapy, and 30% had primary tumour surgery. Mean survival was 5.8 months, significantly shorter than patients with known malignancies (12.3 months; p<0.005).

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Conclusion

Orbital metastasis as the initial malignancy sign correlates with aggressive disease and dismal survival, particularly in undiagnosed cases. Rapid-onset proptosis, diplopia, or orbital pain warrant urgent systemic evaluation, including PET/CT, to identify occult primaries. Multidisciplinary management is critical, though prognosis remains poor, highlighting the need for public health initiatives to improve cancer awareness and early detection in regions with limited healthcare access.

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Additional Authors

First name	Last name	Base Hospital / Institution
Indumati	Gopinathan	ClinicoPath Lab
Rima	Pathak	Tata Memorial Cancer Hospital, Mumbai
Anil	Tibrewal	Tata Memorial Cancer Hospital, Mumbai

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