Acellular Collagen Matrix: A Novel Asset for Multi-Tissue Reconstruction
Author: Ulrike Schrifl
Base Hospital / Institution: Manchester Royal Eye Hospital
ePoster presentation
Abstract ID: 25-355
Purpose
To demonstrate the use of an acellular collagen matrix combined with an amniotic membrane for fornix and anterior segment reconstruction following complex choristoma excision. Additionally, to review bioengineered acellular dermal matrices, their possible applications in oculoplastic surgery, and to compare them with traditional mucosal reconstruction methods such as buccal mucosa and amniotic membrane grafts.
Methods
We present a case of a 5-month-old infant with a large congenital lesion in the right lateral canthus. Following excision, reconstruction was performed using Geistlich Mucograft®, a porcine-derived acellular collagen bi-layer matrix rich in collagen types I and III, along with Omnigen, a dehydrated human amniotic membrane, to cover the lateral rectus muscle. A literature review on conjunctival replacement techniques and tissue substrates was also conducted.
Results
At one week postoperatively, the grafts demonstrated excellent wound stability without inflammation, infection, or discomfort. No additional ocular movement restriction was observed beyond that caused by the choristoma. At 1 month post surgery, conjunctival tissue is expanding over the mucograft, while extra-ocular movements are full. The patient continues to be monitored, and we aim to present photographic wound healing progression.
Conclusion
Our findings suggest that collagen matrices offer a promising alternative to traditional buccal mucosal grafts in fornix reconstruction. While xenogeneic collagen matrices are widely used in maxillofacial surgery, their application in ophthalmology remains limited. Current reports primarily describe their role as spacers in treating lower lid retraction and anophthalmic socket surgery. In addition to this case, we provide a comprehensive overview of available tissue substitutes, as well as experimental tissue engineering in conjunctival reconstruction, highlighting their individual strengths to improve personalized treatment strategies.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Elspeth | Green | Manchester Royal Eye Hospital |
| Susmito | Biswas | Manchester Royal Eye Hospital |
| Anne | Cook | Manchester Royal Eye Hospital |
