The Effect of Hyaluronidase On Postoperative Ecchymosis and Surgery Duration In Upper Eyelid Blepharoplasty: A Prospective, Randomized, Double-Blinded Study
Author: Tehila Shlomov
Base Hospital / Institution: Hadassah medical center
ePoster presentation
Abstract ID: 25-399
Purpose
Hyaluronidase, enzyme facilitating tissue diffusion, has shown promise in enhancing local anesthesia efficacy in surgical applications. This study Prospective, Randomized, Double-Blinded aims to evaluate its effect on surgical efficiency and postoperative outcomes in upper eyelid blepharoplasty, a common oculoplastic procedure.
Methods
This study enrolled 44 patients (85 eyelids) undergoing upper eyelid blepharoplasty. 8 (18.2%) patients were males and mean age 63.04±9.35 years. Patients with prior eyelid surgeries or additional interventions were excluded, and anti-aggregates were discontinued preoperatively. Patients were randomized into two groups receiving local anesthesia (bupivacaine 0.5%, lidocaine 2%, epinephrine 1:100,000) with or without hyaluronidase. Postoperative ecchymosis was graded by blinded evaluators using modified Hester et al. classification, and surgical duration was recorded. Statistical analyses included χ² tests for categorical variables and t-tests for quantitative comparisons. The relationship between numerical variables was assessed using either the Spearman correlation coefficient.
Results
31 eyelids were included in the group without Hyaluronidase in the local anesthesia and 54 eyelids were included in the hyaluronidase group. The hyaluronidase group showed significantly shorter surgical durations compared to the control group (26.46 ± 11.84 vs. 34.00 ± 10.97 minutes; p=0.025). Postoperative ecchymosis scores were similar between groups (1.13 ± 0.781 vs. 1.065 ± 0.616; p=0.346). Ecchymosis grading and surgical duration were not correlated (r=0.1; p=0.3). No adverse effects were reported.
Conclusion
The addition of hyaluronidase to local anesthesia in upper eyelid blepharoplasty significantly reduced surgical time, potentially improving procedural efficiency. However, its lack of effect on postoperative ecchymosis suggests further research is needed to elucidate the mechanisms underlying these findings.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Ortal | Buhbut | Soroka Medical Center |
| Yossi | Eshel | Hadassah Medical Center |
| Dafna | Landau Prat | Sheba Medical Center |
| Ofira | Zloto | Sheba Medical Center |
| Zvi | Gur | Hadassah Medical Center |
