A Unique Case of Orbital Compartment Syndrome in a Burn Victim with Interleukin 10 Deficiency
Author: Oren Iny
Base Hospital / Institution: Soroka university hospital Israel
ePoster presentation
Abstract ID: 24-309
Purpose
Orbital Compartment Syndrome (OCS) is a rare but severe ocular emergency characterized by increased intra-orbital pressure, which can lead to irreversible vision loss if not promptly treated. This study presents a unique case of OCS in a burn victim with Interleukin 10 (IL-10) deficiency, a novel association in the literature.
Methods
A seven-year-old girl with a history of IL-10 deficiency sustained severe third-degree burns over 70% of her body, including the face and eyelids. She was admitted to the pediatric intensive care unit, where she received extensive treatment including fluid resuscitation, debridement, and transfusions. Oculoplastic evaluation revealed severe periorbital edema and elevated intraocular pressures, leading to an OCS diagnosis. Emergent canthotomy and cantholysis were performed to reduce intraocular pressure, followed by temporary tarsorrhaphy.
Results
Following the procedures, intraocular pressures normalized, and the ocular condition improved significantly. Despite these improvements, the patient developed severe systemic complications, including pneumonia, hemodynamic instability, and an arterial thrombus, ultimately leading to her death after sixteen days of hospitalization.
Conclusion
This case underscores the critical role of IL-10 in regulating immune responses and its impact on burn injury outcomes. IL-10 deficiency likely contributed to the rapid progression from thermal burns to severe sepsis and OCS. Prompt recognition and treatment of OCS facilitated a favorable ocular prognosis, but the patient’s systemic condition deteriorated due to underlying immunological challenges. This report highlights the need for heightened vigilance and rapid intervention in similar cases to prevent severe vision loss and manage systemic complications effectively.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Konstantin | Yaakov Gushansky | Soroka university hospital Israel |
