Characteristics of ocular adnexal lymphoma and their long term follow up at a tertiary referral centre in the United Kingdom
Author: Hetvi Bhatt
Base Hospital / Institution: University Hospitals of Leicester NHS Trust
ePoster presentation
Abstract ID: 24-331
Purpose
Lymphoma is a lymphoproliferative disorder that can affect sites and organs that are separate from lymph nodes. We analysed cases of ocular adnexal lymphoma presenting to a tertiary referral centre in the East Midlands for subtypes of lymphoma, treatment, and subsequent relapse.
Methods
Retrospective case analyses of orbital adnexal biopsies taken between 2010-2022 with a histological diagnosis of lymphoma. Cases were reviewed for past history of lymphoproliferative disease and followed up to look at treatment and subsequent relapse.
Results
62 patients with ocular adnexal lymphoma were followed up for an average of 65.7 months (range 1-273). Their mean age at presentation was 65.1 ¬¬± 16.9 years, with male:female ratio of 1:1.
Biopsy sites ranged from orbit (32; 51.6%), lacrimal gland (10; 16.1%), conjunctiva/caruncle (11; 17.7%), or lids (7; 11.3%). The most common subtypes of lymphoma were marginal zone lymphoma (MZL) (50.0%), followed by diffuse large B cell (DLBCL) (21.0%), follicular (FL) (9.7%), mantle cell (MCL) (8.1%).
Treatment varied with subtype and although radiotherapy was most frequently used, chemotherapy was offered to 80.0% in MCL but only 19.4% in MZL.
25 patients (40.3%) had a previous history of lymphoma. Average time from diagnosis of lymphoma to orbital involvement was 79.6 months (range 2-251). Of the 37 (59.7%) newly diagnosed lymphoma from biopsy, further investigation revealed 13 (21.0%) had systemic disease already, and a further 7 (11.3%) developed systemic involvement. In total, 25 (40.3%) patients had disease localised to the orbit without systemic involvement throughout the period of follow up.
Conclusion
Almost 2/3 of biopsies demonstrating lymphoma originated from the orbit or lacrimal gland. MZL was the most common diagnosis affecting half of our patients. Whilst 40% had a previous history of lymphoma, 60% had a new diagnosis from biopsy. On follow up, 25 out of 62 patients have lymphoma purely localised to orbits without systemic spread.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Jennifer | Kwan | University Hospitals of Leicester NHS Trust |
| Kristin | Cowan-Lyn | University Hospitals of Leicester NHS Trust |
| Raghavan | Sampath | University Hospitals of Leicester NHS Trust |
