Changes in Eyelid Laxity and Effects on Ocular Surface Parameters with Increasing Degrees of Obstructive Sleep Apnea Syndrome
Author: Husnu Can Yasar
Base Hospital / Institution: Marmara University Medical Faculty Department of Ophthalmology
ePoster presentation
Abstract ID: 24-529
Purpose
To determine varying eyelid laxity and signs, symptoms of ocular surface disease by increasing severity of obstructive sleep apnea syndrome(OSAS)
Methods
Fifty-one patients with OSAS (21 mild, 30 severe OSAS) and 22 healhty individuals as the control group were included in this study. The severity of OSAS was determined based on the Apnea Hypopnea Index (AHI). Upper eyelid eversion, medial canthal laxity (MCL) and tarsal exposure (TE) examinations were conducted to asses the severity of eyelid laxity. Ocular surface parameters was conducted, which involved evaluating ocular surface staining, Marx’ line, lid wiper epitheliopathy, tear break-up time, non-invasive tear break-up time (NI-TBUT), the Schirmer test, lower eyelid meibomian gland loss (MGL) area, assessing and administering the Dry Eye Questionnaire (DEQ-5).
Results
There were no significant difference in age distribution among the three groups (p=0.399). Mean DEQ-5 scores were 4.57±1.08, 4.33±1.00,4.10±0.71 for control, mild OSAS, severe OSAS groups respectively (p=0.066). Schirmer, TIBUT and NIBUT test results did not show any statistically significant differences between the groups (p=0.08, p=0.90, p=0.29, respectively). MGL percentages yielded statistically significant differences between the groups (p=0.001). Differences were detected between mild and severe OSAS groups (p=0.002) and control and severe OSAS groups (p=0.006). Statistically significant differences detected in meibography grades betweeen mild and severe OSAS groups (p=0.048); and between the control group and severe OSAS group (p=0.024).Marx line, eversion and tarsal exposure measurment values were statistically significant between the three groups (p<0.001, p=0.003, p=0.013, respectively). Tarsal exposure grades are significantly different between control group and severe OSAS group (p=0.015).
Conclusion
This study suggests that OSAS, a condition suspected to involve disruption in elastin metabolism, may be associated with changes in eyelid dynamics and dry eye symptoms. The severity of OSAS may further influence these ocular changes.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Volkan | Dericioglu | Marmara University Medical Faculty Department of Ophthalmology |
| Gamze | Ozkan Cat | Marmara University Medical Faculty Department of Ophthalmology |
| Handenur | Tunc | Marmara University Medical Faculty Department of Neurology |
| Gulin | Sunter | Marmara University Medical Faculty Department of Neurology |
| Semra | Akkaya Turhan | Marmara University Medical Faculty Department of Ophthalmology |
