ePoster listing and sessions

Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London

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Acute Myeloid Leukaemia Relapse Diagnosed by Orbital Myeloid Sarcoma. A Rare Case Report.

Author: Chafik KEILANI
ePoster Number: 214

Purpose

Direct infiltrations of ocular and orbital tissues by leukemic cells are uncommon. They may be misdiagnosed and considered as chronic allergic conjunctivitis, delaying treatment. Here, we report a case of a left ocular myeloid sarcoma revealing acute myeloid leukemia (AML) relapse in a 25-years-old French Man.

Methods

The patient presented a hard, well defined, left perilimbal mass. This finding was first considered as an allergic conjunctivitis by the general practitioner. The patient was treated with antiallergic eye drops with no results. Consequently, the patient was referred to our department and an orbital magnetic resonance imaging (MRI) was performed. The MRI showed a tissular tumor on the left lacrimal sac and the periocular region. We decided a transconjunctival biopsy of the perilimbal mass.

Results

The anatomopathological examination revealed an ocular and orbital myeloid sarcoma. Molecular analysis of the perilimbal biopsy showed FLT3-ITD and IDH1 mutation. The patient had a history of AML in remission. Based on the medical history, we established the diagnosis of extramedullary AML relapse. Subsequently, the patient was referred to the hematology department. He underwent a chemotherapy and targeted therapy.

Conclusion

Ocular leukemic infiltrates are very rare during AML (3% cases at the time of diagnosis). Myeloid sarcoma should be considered as a differential diagnosis for conjunctival ocular surface tumors, especially in adults. Hematological investigations may detect AML in such systemically asymptomatic cases.

Additional Authors

Abstract ID: 20-119