Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Decreasing Optic Nerve Head Vessel Density from the Graves’ disease to the Dysthyroid Optic Neuropathy; Does the Ischemic Optic Neuropathy play a role?
Author: Mohsen Kashkouli
ePoster Number: 216
Purpose
To compare the retinal peripapillary capillary (RCP) vessel density (VD) between the 5 groups of the patients in the spectrum of the thyroid eye disease (TED).
Methods
It is a prospective comparative study. Healthy volunteers (39 eyes, 20 subjects), Graves’ disease without TED (26 eyes, 13 patients), mild TED (28 eyes, 14 patients), moderate-severe TED (30 eyes, 17 patients), and dysthyroid optic neuropathy (DON) (21 eyes, 12 patients) were included from January 2018 to March 2021. Ocular and periocular examination, visual filed indices, RPC-VD (optical coherence tomography angiography), and retinal nerve fiber layer and macular ganglion cell complex thickness were recorded.
Results
Initial insignificant (0.5<P<0.9) rise in the pp-VD and wi-VD from the healthy subject to the Graves’ disease without TED was followed by a significant (P=0.001) fall in the different severity grades of the TED. The paired comparison between the 5 groups showed that the statistically significant fall from the Graves’ disease group occurred in the moderate-severe and DON groups (0.001≤P≤0.04). No variable significantly affected the VD (0.08≤P≤0.9). A lower wi-VD and pp-VD were significantly (0.001≤P≤0.009) correlated with the impaired optic nerve functional and structural tests. The sensitivity and specificity of wi-VD (81% and 76%) and pp-VD (69% and 71%) for detecting the DON were significant (P<0.001).
Conclusion
Despite an insignificant rise in the wi- and pp-VD from the healthy volunteers to the Graves’ disease without TED, they showed a declining trend in the course of TED which was significant in the moderate-severe and DON groups.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Parya | Abdolalizadeh | Iran University of Medical Sciences |
| Farideh | Moradpasandi | Iran University of Medical Sciences |
| Khalil | Falavarjani | Iran University of Medical Sciences |
| Reza | Mirshahi | Iran University of Medical Sciences |
| Shadi | Akbarian | Iran University of Medical Sciences |
Abstract ID: 21-103