Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Orbital Mucormycosis associated with SARS/CoV-2 Infection
Author: Farzad Pakdel
ePoster Number: 219,00
Purpose
We faced a surge in incidence of mucormycosis during COVID-19 pandemic among patients with SARS/CoV-2 Infection. We aim to report clinical features, contributing factors and outcome among patients with COVID-19-associated mucormycosis (CAM).
Methods
This was a prospective multicenter study on patients with biopsy proven sinu-orbital mucormycosis among patients with RT-PCR confirmed COVID-19 from April 2020 to September 2020 during COVID-19 Pandemic. Demographics, time interval between COVID-19 disease and mucormycosis, underlying systemic diseases, clinical features, course of disease and outcome were collected and analyzed.
Results
Fifteen patients with COVID-19 and rhino-orbital mucormycosis were included. Mean age of patients was 51.73±14.72 years. Sixty-six percent of patients were male. The mean interval time between COVID 19 disease and mucormycosis was seven days (range: 1-37 days). Most patients had advanced mucormycosis at admission. The most common presentation was orbital apex syndrome (73%). Eight (53%) patients had cavernous sinus thrombosis. Among patients 13 (86%) had diabetes mellitus, seven (46.6 %) had received intravenous corticosteroid. Seven (47%) patients died from mucormycosis. Six (40%) received combined anti-fungal therapy and five patients (33%) underwent orbital exenteration. None of patients that received combined anti-fungal therapy died.
Conclusion
Findings of this study showed that clinicians should be cautious about mucormycosis during the first two weeks after COVID 19 in high-risk patients. CAM may be more advanced and aggressive course. Poor control of diabetes mellitus and ,corticosteroid therapy and severe pulmonary involvement during COVID-19 seem important underlying predisposing factors.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Mohammadreza | Salehi | Emam Hospital/Tehran University of Medical Sciences |
| Kazem | Ahmadikia | Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences |
| Azin | Tabari | Emam Hospital/Tehran University of Medical Sciences |
| Rozita | Jafari | Emamhossein Hospital/Shahisbeheshti University of Medical Sciences |
| Sadegh | Khodavaisy | 2Department of infectious diseases and Tropical Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences |
Abstract ID: 21-109
