Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Histopathological and Functional Analysis of Nasal Mucosa in Primary and Revision Dacryocystorhinostomy: A Comparative Study
Author: Nazan Acar Eser
ePoster Number: 230,00
Purpose
This study evaluated the histopathological and functional characteristics of nasal mucosa in primary and revision dacryocystorhinostomy (DCR) focused on key histological differences, and inflammatory changes, and examined clinical factors contributing to revision surgery. Furthermore, it assessed the impact of these histopathological and clinical variations on surgical outcomes and long-term DCR success.
Methods
Forty-five patients (24 primary, 21 revision DCR) were enrolled. Assessments included the history of dacryocystitis, asthma, allergic rhinitis, epiphora duration, and recent nasal spray use. Histopathological analysis examined inflammation, subepithelial fibrosis, goblet cell density, and mucous gland density. Patients were evaluated at 1 and 6 months postoperatively.
Results
Dacryocystitis and purulent secretion were more common in primary cases (p = 0.001, p = 0.013). Allergic rhinitis and asthma correlated with purulent secretion (p = 0.012). Histopathology showed higher goblet cell density in primary cases and more subepithelial fibrosis in revision cases (p = 0.001, p = 0.003). Symptom duration in primary cases correlated with inflammation and fibrosis (p = 0.001, p = 0.002, r = 0.622; p = 0.042, r = 0.429). In revision cases, the non-use of nasal spray and the absence of asthma/allergic rhinitis were linked to lower inflammation (p = 0.002, p = 0.022). Overall, asthma/allergic rhinitis (p = 0.026) and nasal spray use (p = 0.015) were associated with higher inflammation.
Conclusion
This prospective study highlights notable differences between primary and revision DCR beyond surgical technique and bone ostium size. Primary cases had higher mucosal and submucosal gland densities, while revision cases showed more fibrosis. Rhinitis and asthma worsened symptoms and histopathological changes, and nasal spray use increased mucosal inflammation. These findings suggest that DCR outcomes depend not only on surgery but also on nasal mucosal characteristics, allergic conditions, and nasal spray use.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Fatih Kağan | Değirmenci | University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, Ankara, Turkey |
| Fatma | Aslan Yay | University of Health Sciences, Ankara Training and Education Hospital, Medical Pathology Department |
Abstract ID: 25-126
