Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Second Primary Malignancies: hidden threats of survival in ocular adnexal extranodal marginal zone lymphoma.
Author: Shang-Te Ma
ePoster Number: 110,00
Purpose
Ocular adnexal extranodal marginal zone lymphoma (OA-EMZL) possessed excellent survival prognosis and complete remission rate; nevertheless, previous studies have proved that the incidence of second primary malignancies (SPMs) significantly increased in systemic lymphoma patients. No exclusive literature had provided information regarding SPM in OA-EMZL so far. We therefore aimed to reveal the outcomes of OA-EMZL and the concurrence of SPMs.
Methods
We performed a 30-year retrospective cohort study in a tertiary center from January 1995 to November 2024. Patients with primary OA-EMZL were included. Patient demographics, AJCC 8th staging, overall survival (OS) and recurrence free survival (RFS) were collected and analyzed. We also collected the characteristics of SPMs and analyzed the effects of SPMs on survival rates in OA-EMZL patients.
Results
There were 380 OA-EMZL patients enrolled in this study with a median follow-up period of 56 months (range: 1 – 294). The mean age was 49.83±14.24 years, and male sex comprised of 47.6%. Among these patients, complete remission was achieved in 95%. The 5- and 10-year overall survival (OS) rates were 94.5% and 87.5%; 5-and 10-year recurrence free survival (RFS) rates were 93.6% and 85.1%, respectively. Older age (p < 0.001), advanced N (p = 0.0212) and M (p = 0.0383) staging contributed to worse RFS. A total of 43 patients (11.3%) had SPMs during the follow-up period, and the most prevalent location was in the gastrointestinal tract (n = 12, 27.9%). Patients with SPM were significantly older (57.98±13.83 versus non-SPM: 48.79±13.98 years, p < 0.001), and associated with less favorable OS (hazard ratio: 3.00, 95% CI 1.01 – 9.91, p = 0.047).
Conclusion
Excellent survival prognosis and favorable complete remission rate are the hallmark of OA-EMZL; nevertheless, older age was related to less optimal survival outcomes. Secondary primary malignancies (SPM) might develop as patients aging and led to unfavorable survival rates. Clinicians should be aware of the possible comorbidity of SPM and undertake multidisciplinary scrutinization for OA-EMZL patients periodically.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Kyung In | Woo | Samsung Medical Center, Sungkyunkwan University School of Medicine |
Abstract ID: 25-234
