Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Study of the Neutrophil-to-Lymphocyte Ratio as a Biomarker in Thyroid Eye Disease
Author: Santiago Ortiz-Perez
ePoster Number: 153,00
Purpose
To evaluate the usefulness of the neutrophil-to-lymphocyte ratio (NLR) as an inflammatory biomarker in thyroid eye disease (TED), and its ability to differentiate between active and inactive phases based on the Clinical Activity Score (CAS).
Methods
A retrospective observational study was conducted using 140 records from 114 patients diagnosed with TED in a dedicated referral clinic. For each patient, the highest and lowest CAS scores available were identified as representations of the active (CAS ≥ 3) and inactive (CAS < 3) phases, respectively. Neutrophil and lymphocyte counts from the closest laboratory tests were collected, and the NLR was calculated. Additional variables such as age, sex, smoking status, and thyroid hormone levels were also recorded. Descriptive statistics were followed by Mann-Whitney U tests, Spearman correlation, binary logistic regression, and ROC analysis to assess diagnostic performance.
Results
Although the NLR was slightly higher in the active phase group, the difference was not statistically significant (p = 0.63). Correlation between NLR and CAS was negligible (rho = 0.0185; p = 0.83). Logistic regression showed a weak association, and ROC analysis revealed low discriminative capacity (AUC = 0.57). Diagnostic thresholds for NLR offered limited sensitivity and specificity.
Conclusion
In our cohort, NLR did not demonstrate sufficient reliability to be used as a standalone biomarker for inflammatory activity in TED. Despite the systemic nature of the disease, NLR failed to reflect clinical activity reliably. These findings highlight the need for further prospective studies with better control of confounding variables and a higher representation of active-phase patients.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Manuel Rafael | Viedma-Perez | University of Granada |
| Sara | Aguayo-García | Hospital Virgen de las Nieves |
| Javier | De la Oliva | Hospital Virgen de las Nieves |
| Francisco | Zamorano-Martín | Hospital Virgen de las Nieves |
Abstract ID: 25-253
