Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London
(plain text version here)
Nomogram-Based Prediction of Implant Exposure Risk After Enucleation or Evisceration With Primary Implantation
Author: Minghui Wang
ePoster Number: 255,00
Purpose
To develop a predictive nomogram for assessing the risk of implant exposure following enucleation or evisceration with primary implantation, based on potential clinical risk factors.
Methods
This retrospective study included clinical data from 336 patients who underwent enucleation or evisceration with primary orbital implantation at our hospital. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of implant exposure. A nomogram was then constructed based on these predictors. The model’s performance was assessed using the concordance index (C-index), receiver operating characteristic (ROC) curve, and area under the curve (AUC). Clinical utility was further evaluated using decision curve analysis (DCA).
Results
Multivariable analysis identified the following as independent risk factors for implant exposure: previous ocular trauma (OR, 2.082; 95% CI, 1.006-4.310; P= 0.048), diabetes mellitus (OR, 4.172; 95% CI, 1.807-9.634; P<0.001), autoimmune diseases(OR, 4.687; 95% CI, 1.150-19.093; P=0.031), chemotherapy or radiotherapy for cancer(OR, 4.249; 95% CI, 1.089-16.576; P=0.037), hormone therapy (OR, 2.351; 95% CI, 1.043-5.300; P=0.039), and previous ocular surgery (OR, 2.651; 95% CI, 1.332-5.274; P=0.005). A nomogram was established with these variables. The AUC of the nomogram was 0.725 in both the training and validation datasets, indicating good discriminatory ability. Calibration curves demonstrated good agreement between predicted and observed outcomes, and DCA confirmed the clinical utility of the model.
Conclusion
This study identified several clinical risk factors associated with implant exposure following enucleation and evisceration with primary implantation. The developed nomogram provides a reliable tool to assist ophthalmologists in identifying high-risk patients and formulating individualized preventive strategies.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Ludwig M | Heindl | Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. |
| Wanlin | Fan | Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. |
| Alexander C | Rokohl | Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany. |
Abstract ID: 25-351
