Purpose

Squamous cell carcinoma (SCC) of the eye is a rare malignancy that is part of the spectrum of ocular surface squamous
neoplasia (OSSN). Numerous fixed and modifiable risk factors have been identified, such as male gender, age, cigarette smoking, UV
radiation, and immunosuppression. Every conjunctival lesion requires a differential diagnosis between benign and malignant diseases, and
all suspicious lesions should be biopsied. The aim of the study is to present patients with OSSN of the conjunctiva and/or cornea
who were treated at the Eye Diseases Clinic in Banja Luka. All patients with pathohistologically confirmed SCC of the conjunctiva
underwent wide non-contact surgical resection, with conjunctival cryotherapy and application of absolute alcohol to the cornea.
Postoperatively, all patients with SCC were prescribed local therapy with Mitomycin C 0.04% according to the treatment protocol with the
approval of the oncology council and regular monitoring by an ophthalmologis

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Methods

The paper presents 5 patients with
conjunctival and/or corneal tumors who were treated at the Clinic for Eye Diseases in the period from 2023-2025. Patients with SCC of the
conjunctiva and/or cornea after surgical excision and cryotherapy of the conjunctiva received local mitomycin C 0.04% according to the
treatment protocol with the approval of the oncology council. The main outcome measures of therapy were tumor response and side effects
of the drug.

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Results

Patients with confirmed conjunctival SCC demonstrated efficient and successful clinical treatment of conjunctival
squamous cell carcinoma by excision and postoperative treatment with local MMC 0.04% without disease recurrence in the follow-up to
date.

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Conclusion

Timely diagnosis and combination of surgical excision and local therapy with Mitomycin C in squamous cell carcinoma of
the conjunctiva proved to be effective in terms of patient follow-up and disease recurrence

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Additional Authors

First name	Last name	Base Hospital / Institution
Biljana	Trivunčevic-Simetic	University Clinical Centre of Republic of Srpska

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