Abstract ID: 26-272
Prostate Cancer Metastases to the Orbit: A Systematic Review of Biopsy-Confirmed Radiological Characteristics
Author: Joseph Brooks Base Hospital / Institution: University Hospitals Sussex NHS Foundation Trust, United Kingdom
Presentation Type: ePoster Presentation
Purpose
To review lesion-level radiological characteristics of biopsy-confirmed prostate cancer metastases to the orbit.
Methods
We searched PubMed Title/Abstract for (“orbit” OR “orbital”) AND metastasis AND “prostate cancer”. Records (n=93) underwent screening and full-text review using prespecified criteria. Inclusion required (i) an orbital lesion with radiological description and (ii) pathologic confirmation from the orbital mass or a directly contiguous sinonasal or skull-base component of the same radiologically continuous lesion. Thirty cases (1972–2025) met criteria. Data were extracted for modality/technique, location/laterality, bone pattern, morphology/size, and signal/enhancement/PET.
Results
Almost all cases (28/30, 93.3%) were characterised with CT and/or MRI. CT was most frequent (23/30, 76.6%); including contrast-enhanced CT in 8/30 (26.6%). MRI was used in 14/30 (46.6%), with gadolinium enhancement in 3/30 (10.0%). Ultrasound was used in 4/30 (13.3%). PET was infrequent (2/30, 6.6%): fluorodeoxyglucose (FDG) uptake was mild when present, whereas Prostate-Specific Membrane Antigen Positron Emission Tomography (PSMA PET)/CT (1 case) was avid. Lesions comprised (1) bone-based metastases, (2) soft-tissue-only metastases commonly involving fat and/or extraocular muscles, and (3) purely ocular metastases. Lesions most frequently involved the greater wing of the sphenoid/orbital roof, commonly with posterior ethmoid contiguity and apical/optic canal crowding. Bone change was reported in 19/30 (63.3%), usually sclerotic or hyperostotic, although lytic and mixed patterns occurred.
Conclusion
Greater wing of the sphenoid/orbital roof prostate cancer metastases predominate, but soft-tissue-only and purely ocular disease also occur. Definitive diagnosis requires biopsy of the orbital lesion or a directly contiguous component of the same radiologically continuous mass.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Peter | Garside | University Hospitals Sussex NHS Foundation Trust, United Kingdom |
| Saul | Rajak | University Hospitals Sussex NHS Foundation Trust, United Kingdom |
| Huw | Oliphant | University Hospitals Sussex NHS Foundation Trust, United Kingdom |