Abstract ID: 26-337
Patient Journey Prior to Thyroid Eye Disease Diagnosis: UK Findings from a Global Real-World Study
Author: Ann Xi Base Hospital / Institution: Amgen
Presentation Type: ePoster Presentation
Purpose
Real-world evidence on thyroid eye disease (TED) using large-scale population-level data is limited. A global observational study is underway to characterize TED patient journeys. Here, we present findings on pre-diagnosis journeys among patients in the UK.
Methods
We used General Practice (GP) Clinical Practice Research Datalink (CPRD Aurum) and Hospital Episode Statistics (HES; inpatient, outpatient) data to identify newly diagnosed TED patients between 1 Jan 2010 and 31 Mar 2024. Demographics, healthcare consultations, thyroid dysfunction, and TED-related signs or symptoms were assessed 12-months pre-diagnosis (baseline). TED-related signs or symptoms were identified using diagnosis codes for diplopia, proptosis, ocular pain, strabismus, orbital inflammation, keratoconjunctivitis, visual disturbance, optic neuropathy, lid retraction, and other eye/adnexa disorders.
Results
4,115 patients with TED were identified: 76% female, 76% white, median (IQR) age 52 years (41, 64). Nearly all (n=4,080) had baseline healthcare consultations, including ophthalmology (58%) and endocrinology (51%). Overall, 58% (n=2,385) had ≥1 baseline thyroid-related diagnosis recorded, most commonly hyperthyroidism (87%). Only 15% (n=614) patients had ≥1 baseline TED-related signs or symptoms recorded; most frequent signs or symptoms were keratoconjunctivitis (36%), diplopia (31%), proptosis (16%), ocular pain (8%), and strabismus (7%).
Conclusion
In this large UK cohort, most patients had healthcare consultation in the year preceding their initial TED diagnosis, yet few had documented TED-related signs or symptoms in GP setting. Our findings suggest potential under-recognition or under-recording in routine clinical data, highlighting opportunities to improve clinician awareness and identification of TED.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Kristien | Boelaert | University of Birmingham |
| Mark | Lillie | Amgen |
| Andreas | Ochs | Amgen |
| Elizabeth | Richards | Amgen |
| Michael | Duxbury | Amgen |