Purpose

To evaluate the clinical outcomes of “Minibleph,” a standardized non-incisional fractional carbon dioxide laser protocol for periocular rejuvenation using reproducible laser settings and application patterns.

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Methods

This prospective 3-month case series included 22 eyes with periocular wrinkles, eyelid skin laxity, and mild dermatochalasis treated using a fractional ablative carbon dioxide laser in Combo™ mode. Pre- and post-treatment assessment included skin laxity, texture, pigmentation, dermatochalasis grading, standardized eyelid measurements, and patient-reported outcome questionnaires.

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Results

At 3 months, all patients demonstrated improvement in skin laxity and texture, with 54.5% of eyes achieving 75 to 100% improvement. No post-inflammatory hyperpigmentation occurred. Significant improvement was observed in eyelid fold height (p = 0.048), margin reflex distance 1 (p = 0.008), and palpebral fissure width (p = 0.008). Dermatochalasis grade improved significantly (p = 0.034), with improvement seen in 50% of eyes. FACE-Q scores demonstrated significant improvement in upper and lower eyelid appearance (p = 0.003). Mean Recovery Early Symptoms score was low at 25.55/100, while Satisfaction with Outcome was high at 78.82/100.

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Conclusion

The Minibleph protocol provides a safe and reproducible approach for periocular rejuvenation using fractional carbon dioxide laser technology, with measurable improvement in skin laxity, texture, and mild dermatochalasis. This standardized non-surgical technique represents an effective option for selected patients, although moderate to severe dermatochalasis continues to require surgical correction.

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Additional Authors

First name	Last name	Base Hospital / Institution
María Alejandra	Amesty	Vissum Grupo Miranza Alicante
Ronald Steven II	Medalle	Vissum Grupo Miranza Alicante

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