Abstract ID: 26-618
Thyroid eye disease in the United Kingdom: a scoping review of epidemiology, disease burden and service provision in the era of targeted therapies
Author: Abdullah Shakeel Base Hospital / Institution: Princess Alexandra Hospital NHS Trust
Presentation Type: Rapid Fire Presentation Session: Orbit & Non-Surgical TopicsDate: 11th SeptemberTime: 08.51AM
Purpose
Targeted therapies are changing thyroid eye disease (TED) management, increasing the need for UK data on epidemiology, disease burden and treatment-eligible populations.
Methods
MEDLINE, Embase, Cochrane Library and Scopus were searched for UK adult studies evaluating TED epidemiology, severity, healthcare use, psychosocial burden and surgery. Population-based, registry, cohort and relevant case series studies were included; non-UK, paediatric and non-original-data studies were excluded. Two reviewers independently screened records and undertook narrative synthesis by study domain.
Results
The search identified 991 records; 13 studies were included. Studies were heterogeneous, comprising Graves’ disease cohorts, specialist TED clinic series, national surgical database studies, severe disease surveillance cohorts and service surveys. Variation in populations, denominators and outcome reporting limited population-level epidemiological synthesis. Graves’ cohorts reported TED/Graves’ orbitopathy prevalence of 15.4–34%, while national surveillance estimated dysthyroid optic neuropathy incidence at 0.75/million/year. Evidence was stronger for disease burden and service utilisation than for population epidemiology, highlighting delayed referral, moderate-to-severe disease burden, immunosuppressive treatment use, decompression burden, regional variation in surgical access and psychosocial impact.
Conclusion
UK TED literature provides insight into burden and service demand but lacks standardised population-level epidemiology. This is increasingly relevant as targeted therapies enter European practice and services require estimates of eligible populations, capacity and resource implications. Future work should prioritise prospective MDT registries and standardised national datasets to better define TED burden and service requirements.
Additional Authors
| First name | Last name | Base Hospital / Institution |
|---|---|---|
| Samaa | Minhaas | King’s College London |
| Sabah | Janjua | Moorfields Eye Hospital NHS Foundation Trust |
| Reece | Khan | King’s College London |
| Desta | Bokre | Moorfields Eye Hospital NHS Foundation Trust |
| Jimmy | Uddin | Moorfields Eye Hospital NHS Foundation Trust |