ePoster listing and sessions

Topic: ESOPRS 2021 ePoster sessions
Time: Sep 17, 2021 16:00 Amsterdam, Berlin, Rome, Stockholm, Vienna, 15:00 London



(plain text version here)

Back to previous page

5-Fluorouracil injections for the management of post-surgical scarring of the periocular region

Author: Nina Jovanovic
ePoster Number: 112


Skin and conjunctive tend to scar after periocular reconstructive surgeries. A limited number of options are available to prevent and treat scars. This study aims to determine the beneficial effects of 5-fluorouracil (5-FU) antimetabolite injections on scars and fibrotic tissue after periorbital surgical procedures.


An interventional, prospective case series of seven patients was obtained. The outcomes of serial 5-FU injections during three to seven courses of injections with 2 weeks intervals were evaluated during a minimum of 6-months follow-up. Photos before and after each session were taken for independent reviewer evaluation; a patient macroscopic evaluation of redness, scar thickness/depth, inflammation/infection, tissue smoothness, grading findings on a scale of 1 to 5 was performed by the surgeon; and a patient satisfaction questionary before and after each procedure using Likert-type scale where and results were compared.


Patients’ age ranged from 7 to 65 years old. Indications for injectables included free-graft retraction and scarring, cicatricial ectropion, and hypertrophic lid scarring. All patients experienced an improvement in the scar thickness and strength, tissue flatness, and decrease in redness with a score of 4.6/5, 4.9/5, 5/5/ graded by the surgeon, respectively. Cohen’s kappa agreement between the two reviewers was 0.85. Individual satisfaction and better aesthetic outcome were marked as median value 4.5/5 on the Likert scale. Complications were not observed.


5-FU injections are a safe and beneficial treatment option for patients experiencing mild to severe levels of scarring after the reconstructive procedure of the periorbital region. They are cheap, widely available, and should be adopted in plastic facial practices.

Additional Authors

First nameLast nameBase Hospital / Institution
JasminaAlajbegovic-HalimicPrivate Ophthalmology Practice “Dr. Halimic”

Abstract ID: 21-128